Abstract
THE observation that a variety of murine neoplasms contain a filterable agent capable of inducing a five- to ten-fold increase in plasma lactic dehydrogenase (LDH) activity within 48 h of inoculation into normal mice was reported by Riley et al.1, and confirmed by Mundy and Williams2. Subsequent papers described some of the characteristics of the LDH-elevating agent3,4, reported a 50- to 1,000-fold rise in plasma LDH and an approximate five-fold increase in anaerobic glycolysis after ‘infection’ of ‘virus-free’ tumours with the LDH-elevating agent5,6, and demonstrated elevated levels of other enzymes, in addition to LDH, in plasma from mice inoculated with this ‘virus’7,8.
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References
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CRISPENS, C. A Lactic Dehydrogenase Elevating Agent in Association with Human Neoplasms. Nature 199, 1202–1203 (1963). https://doi.org/10.1038/1991202a0
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DOI: https://doi.org/10.1038/1991202a0
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