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Nuclear Factors involved in the Radiation-induced Depression of DNA Synthesis of Deoxyribonucleic Acid

Naturevolume 199pages11081109 (1963) | Download Citation



IN experiments described in a previous communication1, it was found that nuclei isolated from regenerating liver of rats given 800 r. whole body irradiation incorporated less tritiated thymidine when assayed in a DNA-synthesizing system2 at various times after irradiation than did non-irradiated controls. Somewhat similar results had been obtained by Van Lancker3, who postulated that the finding might result from direct damage to the DNA template by irradiation. On the other hand, Nygaard4 has suggested that these findings might result from loss of sodium and potassium from the nucleus due to irradiation damage to the nuclear membrane, such as has been demonstrated by Creasey5 in the irradiated spleen.

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  1. 1

    Lehnert, S. M., and Okada, S., Intern. J. Rad. Biol., 5, 323 (1962).

  2. 2

    Bollum, F. G., Anderegg, J. W., McElya, A. B., and Potter, V. R., Cancer Res., 20, 138 (1960).

  3. 3

    Van Lancker, J. L., Biochim. Biophys. Acta, 45, 57 (1960).

  4. 4

    Nygaard, O. F., The Effects of Ionizing Radiations on Immune Processes, 47 (Gordon and Beach, Science Publishers, New York, 1962).

  5. 5

    Creasey, W. A., Biochim. Biophys. Acta, 38, 181 (1960).

  6. 6

    Dounce, A. L., Witter, R. F., Monty, K. J., Pate, S., and Cottone, M. A., J. Biophys. Biochem. Cytol., 1, 139 (1955).

  7. 7

    Dounce, A. L., and Umaña, R., Biochem., 1, 811 (1962).

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  1. Division of Experimental Radiology, University of Rochester School of Medicine and Dentistry, Rochester, New York

    •  & S. OKADA


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