Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Production of Ultra-structural Glomerular Lesions resembling those of Toxæmia of Pregnancy by Thromboplastin Infusion in Rabbits

Nature volume 199, pages 1105–1106 (1963)Cite this article

Abstract

THE characteristic histological abnormalities of toxæmia of pregnancy (pre-eclampsia) are found in glomeruli and consist mainly of endothelial swelling1. Electron microscopic studies of renal biopsies have confirmed that the main change is marked swelling of endothelial and inter-capillary cells, and have shown in addition the frequent occurrence of dark, granular material deposited between the swollen endothelial cells or along the basement membranes2,3.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Pollak, V. E., and Nettles, J. B., Medicine, 39, 469 (1960).

    Article  CAS  Google Scholar 

  2. Hopper, J., Farquhar, M. G., Yamauchi, H., Moon, H. D., and Page, E. W., Obst. and Gynec., 17, 271 (1961).

    Google Scholar 

  3. Mautner, W., Churg, J., Grishman, E., and Dachs, S., Lab. Invest., 11, 518 (1962).

    CAS  PubMed  Google Scholar 

  4. Vassalli, P., Morris, R. H., and McCluskey, R. T., J. Exp. Med. (in the press).

  5. Farquhar, M. G., and Palade, G. E., J. Cell. Biol., 13, 55 (1962).

    Article  CAS  Google Scholar 

  6. Vassalli, P., Simon, G., and Rouiller, C., Amer. J. Path. (in the press)

  7. Shainoff, J. R., and Page, I. H., J. Exp. Med., 116, 687 (1962).

    Article  CAS  Google Scholar 

  8. Lee, L., and McCluskey, R. T., J. Exp. Med., 116, 611 (1962).

    Article  CAS  Google Scholar 

  9. Benacerraf, B., McCluskey, R. T., and Patras, D., Amer. J. Path., 35, 75 (1959).

    CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. P. VASSALLI

    Present address: Department of Pathology, New York University School of Medicine, New York

Authors and Affiliations

  1. Departments of Histology and Pathology, University of Geneva School of Medicine, Switzerland

    P. VASSALLI, G. SIMON & C. ROUILLER

Authors
  1. P. VASSALLI
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. SIMON
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. ROUILLER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

VASSALLI, P., SIMON, G. & ROUILLER, C. Production of Ultra-structural Glomerular Lesions resembling those of Toxæmia of Pregnancy by Thromboplastin Infusion in Rabbits. Nature 199, 1105–1106 (1963). https://doi.org/10.1038/1991105a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1991105a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing