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Production of Ultra-structural Glomerular Lesions resembling those of Toxæmia of Pregnancy by Thromboplastin Infusion in Rabbits

Nature volume 199, pages 11051106 (14 September 1963) | Download Citation

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Abstract

THE characteristic histological abnormalities of toxæmia of pregnancy (pre-eclampsia) are found in glomeruli and consist mainly of endothelial swelling1. Electron microscopic studies of renal biopsies have confirmed that the main change is marked swelling of endothelial and inter-capillary cells, and have shown in addition the frequent occurrence of dark, granular material deposited between the swollen endothelial cells or along the basement membranes2,3.

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Author information

Author notes

    • P. VASSALLI

    Present address: Department of Pathology, New York University School of Medicine, New York.

Affiliations

  1. Departments of Histology and Pathology, University of Geneva School of Medicine, Switzerland.

    • P. VASSALLI
    • , G. SIMON
    •  & C. ROUILLER

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https://doi.org/10.1038/1991105a0

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