Letter | Published:

Production of Ultra-structural Glomerular Lesions resembling those of Toxæmia of Pregnancy by Thromboplastin Infusion in Rabbits

Naturevolume 199pages11051106 (1963) | Download Citation

Subjects

Abstract

THE characteristic histological abnormalities of toxæmia of pregnancy (pre-eclampsia) are found in glomeruli and consist mainly of endothelial swelling1. Electron microscopic studies of renal biopsies have confirmed that the main change is marked swelling of endothelial and inter-capillary cells, and have shown in addition the frequent occurrence of dark, granular material deposited between the swollen endothelial cells or along the basement membranes2,3.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Pollak, V. E., and Nettles, J. B., Medicine, 39, 469 (1960).

  2. 2

    Hopper, J., Farquhar, M. G., Yamauchi, H., Moon, H. D., and Page, E. W., Obst. and Gynec., 17, 271 (1961).

  3. 3

    Mautner, W., Churg, J., Grishman, E., and Dachs, S., Lab. Invest., 11, 518 (1962).

  4. 4

    Vassalli, P., Morris, R. H., and McCluskey, R. T., J. Exp. Med. (in the press).

  5. 5

    Farquhar, M. G., and Palade, G. E., J. Cell. Biol., 13, 55 (1962).

  6. 6

    Vassalli, P., Simon, G., and Rouiller, C., Amer. J. Path. (in the press)

  7. 7

    Shainoff, J. R., and Page, I. H., J. Exp. Med., 116, 687 (1962).

  8. 8

    Lee, L., and McCluskey, R. T., J. Exp. Med., 116, 611 (1962).

  9. 9

    Benacerraf, B., McCluskey, R. T., and Patras, D., Amer. J. Path., 35, 75 (1959).

Download references

Author information

Author notes

    • P. VASSALLI

    Present address: Department of Pathology, New York University School of Medicine, New York

Affiliations

  1. Departments of Histology and Pathology, University of Geneva School of Medicine, Switzerland

    • P. VASSALLI
    • , G. SIMON
    •  & C. ROUILLER

Authors

  1. Search for P. VASSALLI in:

  2. Search for G. SIMON in:

  3. Search for C. ROUILLER in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/1991105a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.