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Production of Ultra-structural Glomerular Lesions resembling those of Toxæmia of Pregnancy by Thromboplastin Infusion in Rabbits

Naturevolume 199pages11051106 (1963) | Download Citation



THE characteristic histological abnormalities of toxæmia of pregnancy (pre-eclampsia) are found in glomeruli and consist mainly of endothelial swelling1. Electron microscopic studies of renal biopsies have confirmed that the main change is marked swelling of endothelial and inter-capillary cells, and have shown in addition the frequent occurrence of dark, granular material deposited between the swollen endothelial cells or along the basement membranes2,3.

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    Present address: Department of Pathology, New York University School of Medicine, New York


  1. Departments of Histology and Pathology, University of Geneva School of Medicine, Switzerland

    • , G. SIMON
    •  & C. ROUILLER


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