Abstract
RECENT observations carried out on isolated and in vitro perfused preparations of the small intestine of the rat have confirmed that sodium is actively transported through the intestinal wall from the mucosal to the serosal side1–5. For such a transport glucose must be present in the mucosal solution; some metabolic inhibitors, 2,4-dinitrophenol (DNP) or monoiodoacetate, when added to the perfusion liquid, inhibit this transport2,6. The chloride ions cross the intestinal wall together with cations and for the transport of these ions, too, an active mechanism has been assumed3,7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gilman, A., and Koelle, E. S., Circulation, 21, 948 (1960).
Gilman, A., and Koelle, E. S., Amer. J. Physiol., 199, 1025 (1960).
Curran, P. F., J. Gen. Physiol., 43, 1137 (1960).
Clarkson, T. W., and Rothstein, A., Amer. J. Physiol., 199, 898 (1960).
Vaughan, B. E., Amer. J. Physiol., 198, 1235 (1960).
Smyth, D. H., and Taylor, C. B., J. Physiol., 136, 632 (1957).
Baillien, M., and Schoffeniels, E., Biochim. Biophys. Acta, 53, 537 (1961).
Milla, E., and Rossi, S., Boll. Soc. Ital. Biol. Sper., 38, 962 (1962).
Wilson, T. H., and Wiseman, G., J. Physiol., 123, 116 (1954).
Krebs, H. A., and Henseleit, K., Hoppe Seyler's Z. Physiol. Chem., 210, 33 (1932).
Barker, S. B., and Summerson, W. H., J. Biol. Chem., 138, 535 (1941).
Van Slyke, D. J., and Neill, J. M., J. Biol. Chem., 61, 523 (1924).
Pfleger, K., Jacobi, H., and Rummel, W., Naunyn–Schmiederberg's Arch. Exp. Path. Pharmacol., 234, 400 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CAPRARO, V., MILLA, E. & BIANCHI, A. Influence of 2,4-Dinitrophenol on Anion Transport by an Intestinal in vitro Preparation. Nature 199, 1099–1100 (1963). https://doi.org/10.1038/1991099a0
Issue Date:
DOI: https://doi.org/10.1038/1991099a0
This article is cited by
-
Some aspects of the functional polarity of epithelia
Protoplasma (1967)
-
Enterale Resorptionsvorg�nge und ihre Beeinflussung
Naunyn-Schmiedebergs Archiv f�r Experimentelle Pathologie und Pharmakologie (1965)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.