Abstract
Josimovich and MacLaren1 have recently reported the presence in human placenta of a component which cross-reacts with rabbit anti-human growth hormone serum. This protein, which gave a reaction of partial identity with human growth hormone, exhibited prolactin activity and was detected in peripheral venous serum at term and in retroplacental serum by the Ouchterlony gel diffusion technique. Further immunochemical, physicochemical, and biological characterization of this cross-reacting placental protein, detectable in fresh saline homogenates of human and simian placenta, has been described by Kaplan and Grumbach2. Immuno-electrophoresis in agar gel (barbital buffer, pH 8.2) and starch gel electrophoresis (discontinuous buffer system of Ferguson and Wallace) indicate that the migration of the placental component differs from that of native and purified human growth hormone. A partially purified preparation of the cross-reacting placental component contains significant growth-promoting activity2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Josimovich, J. B., and MacLaren, J. A., Endocrinol., 71, 209 (1962).
Kaplan, S. L., and Grumbach, M. M., J. Clin. Endocrinol. (in the press).
Leznoff, A., Fishman, J., Goodfriend, L., McGarry, E. E., Beck, J. C., and Rose, B., Proc. Soc. Exp. Biol. (N.Y.), 104, 232 (1960).
Grumbach, M. M., and Kaplan, S. L., Acta Endocrinol. (Copenhagen), 35, Supp. 51, 1101 (1960). Grumbach, M. M., Kaplan, S. L., Hsu, K., and Elftman, H., in Immunoassay of Hormones, Ciba Found. Coll. Endocrinol., 14, 373 (1962).
Coons, A. H., Intern. Rev. Cytol., 5, 1 (1956).
Grumbach, M. M., and Kaplan, S. L., in Immunoassay of Hormones. Ciba Found. Coll. Endocrinol., 14, 63 (1962). Kaplan, S. L., and Grumbach, M. M., Nature, 196, 336 (1962).
Midgley, jun., A. R., and Pierce, jun., G. B., J. Exp. Med., 115, 289 (1962).
Sciarra, J. J., and Tallberg, T. (unpublished results).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SCIARRA, J., KAPLAN, S. & GRUMBACH, M. Localization of Anti-human Growth Hormone Serum within the Human Placenta : Evidence for a Human Chorionic ‘Growth Hormone-prolactin’. Nature 199, 1005–1006 (1963). https://doi.org/10.1038/1991005a0
Issue Date:
DOI: https://doi.org/10.1038/1991005a0
This article is cited by
-
Trinucleate cells and the ultrastructural localisation of bovine placental lactogen
Cell and Tissue Research (1987)
-
Immunohistochemical location of HPL, SP1 and β-HCG in normal placentas of varying gestational age
Archives of Gynecology (1986)
-
Inability of second trimester human amniotic fluid cell cultures to aromatize C19‐steroids
Journal of Inherited Metabolic Disease (1985)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.