Anorexic Effect of Intraperitoneal Glucose in the Hypothalamic Hyperphagic Cat

Abstract

IN previous communications^1,2 one of us reported results leading to the hypothesis that peripheral glucoreceptors (hepatic and, perhaps, muscular) play an important part in the regulation of intake of food. The classical glucostatic theory of the regulation of intake of food³ postulates that the ventromedial hypothalamic area has a mechanism for glucostatic regulation of appetite and feeding. The lack of ventromedial glucoreceptors is regarded by proponents of this theory as being instrumental in the development of the hyperphagia observed when the ventromedial hypothalamus is lesioned bilaterally. This communication presents data concerned with the possibility of glucoreceptors regulating appetite as being located elsewhere than in the ventromedial hypothalamic area.