Letter | Published:

Central Actions of Psychotomimetics

Nature volume 199, pages 10031004 (07 September 1963) | Download Citation

Subjects

Abstract

ALTHOUGH the alterations in human behaviour and mental activity produced by psychotomimetic substances are not necessarily closely related to those observed in the psychoses1, the central modes of action of these substances are nevertheless of considerable interest. It is possible that drugs chemically related, to tryptamine, lysergic acid and the catecholamines block synaptic excitation in certain regions of the central nervous system, such as has been demonstrated in the lateral geniculate nucleus2. These substances may also mimic central inhibitory transmitters3, since certain derivatives depress the excitability of neurones in the cerebral cortex and thalamus4.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , Ann. N.Y. Acad. Sci., 96, 80 (1962).

  2. 2.

    , and , Brit. J. Pharmacol., 18, 217 (1962).

  3. 3.

    , Ann. N.Y. Acad. Sci., 92, 990 (1961).

  4. 4.

    , and , J. Physiol., 165, 274 (1963). , , and (unpublished observations).

  5. 5.

    , and , Intern. Rev. Neurobiol., 4, 217 (1962).

  6. 6.

    , , , , and , Ann. N.Y. Acad. Sci., 96, 251 (1962).

  7. 7.

    , , and , Nature, 197, 367 (1963). , , , and , J. Neurochem., 10, 95 (1963).

  8. 8.

    , and , Nature, 195, 1105 (1962).

  9. 9.

    , and , J. Physiol., 153, 17 (1960). , and (unpublished observations).

Download references

Author information

Affiliations

  1. Department of Physiology, Australian National University, Canberra.

    • D. R. CURTIS
    •  & R. W. RYALL

Authors

  1. Search for D. R. CURTIS in:

  2. Search for R. W. RYALL in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/1991003a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.