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Role of Catalase and Peroxidase in the Metabolism of Leucocytes

Naturevolume 199pages10011002 (1963) | Download Citation

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Abstract

LEUCOCYTES are known to be rich in catalase1 and Myeloperoxidase1–3, yet very little is known concerning the role of these enzymes in leucocyte metabolism. In a. recent investigation by Iyer et al.4 evidence was presented for the formation of hydrogen peroxide by guinea pig exudate leucocytes. An obvious physiological function of catalase or peroxidase, therefore, might be to regulate the intracellular concentration of hydrogen peroxide which, if allowed to accumulate, could become toxic to the cells.

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References

  1. 1

    Vercauteren, R. E., and Gillis-Van Maele, A., Enzymologia, 24, 25 (1962).

  2. 2

    Agner, K., Acta Physiol. Scand., 2, Supp. 8, 1 (1941).

  3. 3

    Schultz, J., and Kaminker, K., Arch. Biochem. Biophys., 96, 465 (1962).

  4. 4

    Iyer, G. Y. N., Islam, M. F., and Quastel, J. H., Nature, 192, 535 (1961).

  5. 5

    Feinstein, R. N., and Dainko, J. L., Cancer Res., 19, 612 (1959).

  6. 6

    Heim, W. G., Appleman, D., and Pyform, H. T., Amer. J. Physiol., 186, 19 (1956).

  7. 7

    Rechcigl, jun., M., Price, V. E., and Morris, H. P., Cancer Res., 22, 874 (1962).

  8. 8

    Stähelin, H., Suter, E., and Karnovsky, M. L., J. Exp. Med., 104, 121 (1956).

  9. 9

    Evans, W. H., and Karnovsky, M. L., Biochem., 1, 159 (1962).

  10. 10

    Price, V. E., Sterling, W. R., Tarantola, V. A., Hartley, jun., R. W., and Rechcigl, jun., M., J. Biol. Chem., 237, 3468 (1962).

  11. 11

    Schultz, J., Shay, H., and Gruenstein, M., Cancer Res., 14, 157 (1954).

  12. 12

    Margoliash, E., and Novogradsky, A., Biochem. J., 68, 468 (1958).

  13. 13

    Fallon, H. J., Feri, III, E., Davidson, J. D., Trier, J. S., and Burk, D., J. Lab. Clin. Med., 59, 779 (1962).

  14. 14

    Frisch-Niggemeyer, W., and Höller, H., Z. Krebsforsch., 60, 291 (1955).

  15. 15

    Margoliash, E., and Schejter, A., in Haematin Enzymes, edit. by Falk, J. E., Lemberg, R., and Morton, R. K., 236 (Pergamon Press, Ltd., London, 1961).

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  1. Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, 14, Maryland

    • MILOSLAV RECHCIGL jun.
    •  & WARREN H. EVANS

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https://doi.org/10.1038/1991001b0

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