Abstract
ANTIBODY production after immunization with particulate antigens is known to persist over long periods of time. By contrast, immunization with soluble antigens in the absence of adjuvants is generally thought to give responses of relatively brief duration. Recently, it has been reported that antibody production continued for several hundred days in rabbits given one or several intravenous injections of a number of soluble antigens1. Antibody produced late in the course of the response gave negative ring tests, failed to sensitize the guinea pig intestine, and could be detected only by a passive hæmagglutination technique. This communication is concerned with similar observations on the response of chickens to intravenous injections of bovine serum albumin (BSA). One major finding of this study is the persistence of precipitating antibody up to 313 days after injection.
Similar content being viewed by others
Article PDF
References
Richter, M., and Haurowitz, F., J. Immunol., 84, 420 (1960). Blumer, H., Richter, M., Cua-Lim, F., and Rose, B., J. Immunol., 88, 669 (1962).
Farr, R., J. Infect. Dis., 103, 239 (1958).
Stavitsky, A. B., and Arquilla, E. R., J. Immunol., 74, 306 (1955). Fiset, L. G., Immunology, 5, 580 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GILDEN, R., ROSENQUIST, G. Duration of Antibody Response to Soluble Antigen. Nature 199, 87 (1963). https://doi.org/10.1038/199087a0
Issue Date:
DOI: https://doi.org/10.1038/199087a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.