Abstract
A FAIRLY good agreement has been found between a stochastic model1,2,5, and a skin tumour production experiment performed by Berenblum and Shubik3. In this experiment development of the skin tumour after a single local exposure of mouse skin to graded concentrations of 9,10-dimethyl-1,2-benzanthracene (DMBA) with subsequent twice-weekly exposure of the same skin area to croton oil was investigated. Since then it has been shown that systemic (oral, intravenous, intraperitoneal) initiation and subsequent local tumour enhancement provokes skin tumours4 (for further references, see ref. 7), and a new and physicochemically well-defined group of tumour-enhancers, the dipole-type compounds, has been established17 (for a comprehensive review, see ref. 8).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Arley, N., and Eker, R., Adv. Biol. Med. Phys., 8, 375 (1962).
Arley, N., and Iversen, S., Acta Path. Microbiol. Scand., 31, 164 (1952).
Berenblum, I., and Shubik, P., Brit. J. Cancer, 3, 109 (1949).
Graffi, A., Scharsach, F., and Heyer, E., Naturwiss., 42, 184 (1955).
Iversen, S., and Arley, N., Acta Path. Microbiol. Scand., 27, 773 (1950).
Merenmies, L., Acta Path. Microbiol. Scand., Supp. 130 (1959).
Niskanen, E. E., Acta Path. Microbiol. Scand., Supp. 159 (1962).
Setälä, K., Prog. Exp. Tumor Res., edit. by Homburger, F., 225 (Karger, Basle and New York, 1960).
Setälä, K., Dammert, K., Setälä, H., Merenmies, L., and Holsti, P., Z. Krebsforsch., 61, 548 (1957).
Setälä, K., Merenmies, L., Niskanen, E. E., Nyholm, M., and Stjernvall, L., J. Nat. Cancer Inst., 25, 1155 (1960).
Setälä, K., Merenmies, L., Stjernvall, L., Aho, Y., and Kajanne, P., J. Nat. Cancer Inst., 23, 925 (1959).
Setälä, K., Niskanen, E. E., Merenmies, L., Nyholm, M., and Stjernvall, L., J. Nat. Cancer Inst., 26, 985 (1961).
Setälä, K., Niskanen, E. E., and Nyholm, M., Naturwiss., 48, 226 (1961).
Setälä, K., Niskanen, E. E., Nyholm, M., Stjernvall, L., and Nyyssönen, O., Acta Path. Microbiol. Scand., Supp. 155, 107 (1962).
Setälä, K., Niskanen, E. E., and Nyyssönen, O., Acta Path. Microbiol. Scand., Supp. 155, 27 (1962).
Setälä, K., Niskanen, E. E., Nyyssönen, O., and Lindroos, B., Acta Path. Microbiol. Scand., Supp. 155, 47 (1962).
Setälä, K., Setälä, H., and Holsti, P., Science, 120, 1075 (1954).
Setälä, K., Äyräpää, O., and Niskanen, E. E., Acta Path. Microbiol. Scand., 54, 39 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NISKANEN, E., ARLEY, N. A Stochastic Model of Carcinogenesis compared with Mouse Skin Tumour Enhancement after Gastric Instillation of 9,10-Dimethyl-1,2-Benzanthracene with Subsequent Local Continuous Exposure to ‘Tween 40’. Nature 199, 83–84 (1963). https://doi.org/10.1038/199083a0
Issue Date:
DOI: https://doi.org/10.1038/199083a0
This article is cited by
-
Mathematical models in oncology: a bird's-eye view
Zeitschrift f�r Krebsforschung und Klinische Onkologie (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
