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Carbamylation of Oxytocin and Arginine-Vasopressin


SYNTHETIC analogues of oxytocin and vasopressin in which the terminal amino group is absent or modified exhibit remarkable differences in biological activity. Whereas desamino-oxytocin is highly active1,2, analogues of oxytocin in which the amino group is substituted by acylation or alkylation retain little pharmacological activity3–5, and some act as antagonists4,6. Similarly, 1-desamino-8-lysine-vasopressin has a relatively high pressor potency1 while 1-N-acetyl-8-lysine-vasopressin is inactive7.

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BISSET, G., POISNER, A. & SMYTH, D. Carbamylation of Oxytocin and Arginine-Vasopressin. Nature 199, 69–70 (1963).

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