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Carbamylation of Oxytocin and Arginine-Vasopressin

Nature volume 199, pages 69–70 (1963)Cite this article

Abstract

SYNTHETIC analogues of oxytocin and vasopressin in which the terminal amino group is absent or modified exhibit remarkable differences in biological activity. Whereas desamino-oxytocin is highly active1,2, analogues of oxytocin in which the amino group is substituted by acylation or alkylation retain little pharmacological activity3–5, and some act as antagonists4,6. Similarly, 1-desamino-8-lysine-vasopressin has a relatively high pressor potency1 while 1-N-acetyl-8-lysine-vasopressin is inactive7.

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Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London, N.W.7

    G. W. BISSET, A. M. POISNER & D. G. SMYTH

Authors
  1. G. W. BISSET
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  2. A. M. POISNER
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  3. D. G. SMYTH
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BISSET, G., POISNER, A. & SMYTH, D. Carbamylation of Oxytocin and Arginine-Vasopressin. Nature 199, 69–70 (1963). https://doi.org/10.1038/199069a0

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