Abstract
THE physiological basis of the bactericidal action of isoniazid (isonicotinic acid hydrazide) on Mycobacterium tuberculosis is unknown, although several hypotheses have been proposed1–4. The work recorded here on the effect of isoniazid on macromolecule synthesis in this organism was prompted by the finding that isoniazid is bactericidal only for actively growing cells5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Davison, A. N., Biochim. Biophys. Acta, 19, 131 (1956).
Zatman, L. S., Kaplan, N. O., Colowick, S. P., and Ciotti, M. M., J. Biol. Chem., 209, 467 (1954).
Albert, A., Nature, 177, 525 (1956).
Schaefer, W. B., J. Bact., 79, 236 (1960).
Schaefer, W. B., Amer. Rev. Tuberc., 69, 125 (1954).
Middlebrook, G., and Cohn, M. L., Amer. J. Public Health, 48, 844 (1958).
Middlebrook, G., Amer. Rev. Tuberc., 65, 765 (1952).
Volkin, E., and Cohn, W. E., in Methods of Biochemical Analysis, edit. by Glick, D., 1, 287 (Interscience Pub. Co., New York, 1954).
Burton, K., Biochem. J., 62, 315 (1956).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).
Harold, F. M., Biochim. Biophys. Acta, 45, 172 (1960).
Cohen, S. S., and Barner, H. D., Proc. U.S. Nat. Acad. Sci., 40, 885 (1954).
Gallant, J., and Suskind, S. R., J. Bact., 82, 187 (1961).
Mackaness, G. B., and Smith, N., Amer. Rev. Tuberc., 67, 322 (1953).
Tsukamura, M., and Mizuno, S., Kekkaku, 37, 29 (1962).
Wimpenny, J. (personal communication).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GANGADHARAM, P., HAROLD, F. & SCHAEFER, W. Selective Inhibition of Nucleic Acid Synthesis in Mycobacterium tuberculosis by Isoniazid. Nature 198, 712–714 (1963). https://doi.org/10.1038/198712b0
Issue Date:
DOI: https://doi.org/10.1038/198712b0
This article is cited by
-
Real-time monitoring of live mycobacteria with a microfluidic acoustic-Raman platform
Communications Biology (2020)
-
Modeling metabolic adjustment in Mycobacterium tuberculosis upon treatment with isoniazid
Systems and Synthetic Biology (2010)
-
Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid
Nature Structural & Molecular Biology (2006)
-
The study of mutagenesis inMycobacterium phlei
Folia Microbiologica (1970)
-
Die Feinstruktur markloser (Remakscher) Nervenfasern bei der Isoniazid-Neuropathie
Acta Neuropathologica (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
