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Stabilities of Some Alkaline Earth Chelates of Tetracycline

Nature volume 198, pages 577–578 (1963)Cite this article

Abstract

SEVERAL authors1,2 have reported that the antibiotic tetracycline enhances the removal of radiostrontium from mice. Theoretical work3,4 has indicated that a suitable reagent for the removal of radiostrontium from the mammalian skeleton should have a greater affinity for strontium than for calcium. We have, therefore, examined the chelation with tetracycline of calcium and strontium and also, for comparison, magnesium. The only reported stability constants for tetracycline chelates are those determined by Albert5 for the chelates of aluminium and some transition metals. The acid dissociation constants for the hydrochloride derivative have, however, been determined by Albert5 and by Stephens et al.6.

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Authors and Affiliations

  1. Chemistry Division, Atomic Weapons Research Establishment, Aldermaston

    D. C. MAXWELL, P. J. A. SMITH & S. P. WILFORD

Authors
  1. D. C. MAXWELL
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  2. P. J. A. SMITH
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  3. S. P. WILFORD
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MAXWELL, D., SMITH, P. & WILFORD, S. Stabilities of Some Alkaline Earth Chelates of Tetracycline. Nature 198, 577–578 (1963). https://doi.org/10.1038/198577b0

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