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Water-induced Cerebral Over-hydration in the Maturing Rat Brain


CEREBRAL injury due to anoxia and ischæmia in the adult rat is accompanied by œdema of the brain1–3. Recent work has shown that swelling of the brain in these circumstances does not occur in rats aged less than ten days4. Although this may be a consequence of the increased resistance of the young mammal to anoxia5,6, there could be primary inability of the brain to develop œdema before a certain stage of development is reached. In order to test the latter possibility, the propensity to develop cerebral œdema following administration of water was investigated in rats of different ages.

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SELLER, M., SPECTOR, R. Water-induced Cerebral Over-hydration in the Maturing Rat Brain. Nature 198, 489–490 (1963).

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