Immunofluorescent Test for Infectious Mononucleosis


THE laboratory diagnosis of infectious mononucleosis is based on the demonstration in the patient's serum of atypical mononuclear cells often accompanied by a rise in titre of heterophile agglutinins for sheep red blood cells1,2. It has been shown by Stuart et al.3 that these agglutinins may be differentiated from Forssman antibody and from naturally occurring sheep cell agglutinins by agglutination-inhibition tests, the antibody associated with glandular fever being absorbed by treated ox cells but not by an emulsion of guinea pig kidney.

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  1. 1

    Paul, J. R., and Bunnell, W. W., Amer. J. Med. Sci., 183, 90 (1932).

    Article  Google Scholar 

  2. 2

    Hobson, F. G., Lawson, Barbara, and Wigfield, Mary, Brit. Med. J., i, 845 (1958).

  3. 3

    Stuart, C. A., Welch, H., Cunningham, J., and Burgess, A. M., Arch. Int. Med., 58, 512 (1936).

    Article  Google Scholar 

  4. 4

    Weir, D. M., Holborow, E. J., and Johnson, G. D., Brit. Med. J., i, 933 (1961).

  5. 5

    Grubb, R., and Swahn, B., Acta Path. Microbiol. Scand., 43, 305 (1958).

    Article  CAS  Google Scholar 

  6. 6

    Cohen, S., Nature, 197, 253 (1963).

    ADS  Article  CAS  Google Scholar 

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JOHNSON, G., HOLBOROW, E. Immunofluorescent Test for Infectious Mononucleosis. Nature 198, 1316–1317 (1963).

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