Abstract
IN the course of an investigation of interferon production in a line of rat tumour cells (DE7R cells), infected with Sindbis virus Δ′,17α-methyltestosterone (‘Dianabol’, Ciba), an androgenic steroid known to increase protein synthesis in rats1 was added to the virus-cell system, in the hope of obtaining higher interferon yields. The effect of ‘Cortisol’ was evaluated at the same time in order to compare the action of a glucocorticoid known to decrease protein anabolism in vivo2 with that of an androgen. The methods used for preparing the interferon and to test for its activity have been previously described in detail3.
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References
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DE MAEYER, E., DE MAEYER, J. Two-sided Effect of Steroids on Interferon in Tissue Culture. Nature 197, 724–725 (1963). https://doi.org/10.1038/197724a0
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DOI: https://doi.org/10.1038/197724a0
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