Abstract
IN Nature of May 12, 1962, L. I. Woolf offered an explanation of ‘severe’ and ‘mild’ X-linked hæmophilia A while discussing gene expression in heterozygotes. He proposed that the plasma-level of antihæmophilic globulin (AHG, AHF, Factor VIII) regulated its rate of synthesis, that is, that ‘end-product (feedback) inhibition’ controlled the synthetic rate. ‘Feedback inhibition’ is known to be a very important regulatory mechanism in biosynthetic pathways, producing small anabolites such as amino-acids, vitamins, etc.1. We can find no documented evidence, however, that ‘feedback inhibition’ is a controlling mechanism in protein synthesis. ‘Feedback inhibition’ should be sharply distinguished in this respect from ‘feedback repression’, which is recognized to be a highly important genetic mechanism concerned with regulating the synthesis of enzymes (proteins) in bacteria1–4.
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MCLESTER, W., GRAHAM, J. Synthesis of Plasma Antihæmophilic Factor. Nature 197, 708 (1963). https://doi.org/10.1038/197708a0
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DOI: https://doi.org/10.1038/197708a0
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