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An Endotoxin-like Fraction extracted from the Cells of Candida albicans

Nature volume 197, pages 516–517 (1963)Cite this article

Abstract

ENDOTOXINS are incompletely characterized cell surface complexes which account for some of the pathogenic properties of Gram-negative bacteria. Material with similar biological characteristics has been identified in certain Gram-positive bacteria and in several plant and animal tissues1. The existence of a ‘toxic principle’ in virulent strains of Candida albicans has been suspected for about a decade2. A recent report by Hasenclever et al.3 strongly supports the presence of such a fraction. Our studies of surface and subsurface antigens of this yeast suggest that several surface materials contained in the aqueous fraction after ethanol-ethyl ether4 or phenol5 extraction of intact yeast cells included a substance or substances with toxic activity comparable with that observed by Hasenclever et al.3. This communication presents evidence that this is indeed the case.

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References

  1. Stetson, C. A., in Cellular and Humoral Aspects of the Hypersensitivity States, edit. by Lawrence, H. S., 442 (Hoeber-Harper, New York, 1959).

    Google Scholar 

  2. Salvin, S. B., J. Immunol., 69, 89 (1952).

    CAS  PubMed  Google Scholar 

  3. Hasenclever, H. F., and Mitchell, W. O., Bact. Proc. (1962); and personal communication.

  4. Ribi, E., Haskins, W. T., Landy, M., and Milner, K. C., Bact. Rev., 25, 427 (1961).

    CAS  PubMed  Google Scholar 

  5. Westphal, O., and Luderitz, O., Angew. Chem., 66, 407 (1954).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Laboratories, The Long Island Jewish Hospital, New Hyde Park, New York

    HENRY D. ISENBERG, JONA ALLERHAND & JAMES I. BERKMAN

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  1. HENRY D. ISENBERG
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  2. JONA ALLERHAND
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  3. JAMES I. BERKMAN
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ISENBERG, H., ALLERHAND, J. & BERKMAN, J. An Endotoxin-like Fraction extracted from the Cells of Candida albicans. Nature 197, 516–517 (1963). https://doi.org/10.1038/197516a0

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