ENDOTOXINS are incompletely characterized cell surface complexes which account for some of the pathogenic properties of Gram-negative bacteria. Material with similar biological characteristics has been identified in certain Gram-positive bacteria and in several plant and animal tissues1. The existence of a ‘toxic principle’ in virulent strains of Candida albicans has been suspected for about a decade2. A recent report by Hasenclever et al.3 strongly supports the presence of such a fraction. Our studies of surface and subsurface antigens of this yeast suggest that several surface materials contained in the aqueous fraction after ethanol-ethyl ether4 or phenol5 extraction of intact yeast cells included a substance or substances with toxic activity comparable with that observed by Hasenclever et al.3. This communication presents evidence that this is indeed the case.
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Hasenclever, H. F., and Mitchell, W. O., Bact. Proc. (1962); and personal communication.
Ribi, E., Haskins, W. T., Landy, M., and Milner, K. C., Bact. Rev., 25, 427 (1961).
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ISENBERG, H., ALLERHAND, J. & BERKMAN, J. An Endotoxin-like Fraction extracted from the Cells of Candida albicans. Nature 197, 516–517 (1963). https://doi.org/10.1038/197516a0
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