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An Endotoxin-like Fraction extracted from the Cells of Candida albicans


ENDOTOXINS are incompletely characterized cell surface complexes which account for some of the pathogenic properties of Gram-negative bacteria. Material with similar biological characteristics has been identified in certain Gram-positive bacteria and in several plant and animal tissues1. The existence of a ‘toxic principle’ in virulent strains of Candida albicans has been suspected for about a decade2. A recent report by Hasenclever et al.3 strongly supports the presence of such a fraction. Our studies of surface and subsurface antigens of this yeast suggest that several surface materials contained in the aqueous fraction after ethanol-ethyl ether4 or phenol5 extraction of intact yeast cells included a substance or substances with toxic activity comparable with that observed by Hasenclever et al.3. This communication presents evidence that this is indeed the case.

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ISENBERG, H., ALLERHAND, J. & BERKMAN, J. An Endotoxin-like Fraction extracted from the Cells of Candida albicans. Nature 197, 516–517 (1963).

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