Abstract
PERRY1, commenting on the latent period between application of heptachlor (I) to susceptible houseflies and onset of signs of poisoning, pointed out that although there is an adequate amount of heptachlor in the insect tissues during this period, onset of signs of poisoning seemed to coincide with the appearance of heptachlor epoxide (II) in the tissues. These observations apply also to aldrin (III) and isodrin (IV)2. 
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References
Perry, A. S., Mattson, A. M., and Buchner, A. J., J. Econ. Entomol., 51, 346 (1958).
Brooks, G. T., Nature, 186, 96 (1960).
Winteringham, F. P. W. (personal communication).
Price, G. M., Biochem. J., 84, 98, P (1962).
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BROOKS, G., HARRISON, A. & COX, J. Significance of the Epoxidation of the Isomeric Insecticides Aldrin and Isodrin by the Adult Housefly in vivo. Nature 197, 311–312 (1963). https://doi.org/10.1038/197311b0
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DOI: https://doi.org/10.1038/197311b0
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