Changes in Liver D-Glucuronolactone Dehydrogenase Activity

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D-GLUCURONOLACTONE dehydrogenase occurs in the non-particulate fraction of liver homogenates, and in the presence of nicotinamide adenine dinucleotide (NAD) converts D-glucuronolactone to D-glucaric acid1. The enzyme is probably responsible for the D-glucaric acid excreted in normal mammalian urine2; its activity is conveniently measured by the specific inhibitory effect of D-glucarate, after heating at acid pH, on β-glucuronidase.

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  1. 1

    Marsh, C. A., Biochem. J., 87, 82 (1963).

  2. 2

    Marsh, C. A., Biochem. J., 86, 77 (1963).

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