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Experimental Evidence for the Degeneracy of the Nucleotide Triplet Code

Nature volume 195, pages 999–1000 (1962)Cite this article

Abstract

EXTENSIVE investigations have been reported recently of the incorporation of labelled amino-acids in cell-free protein-synthesizing systems to which synthetic polynucleotides of known compositions were added. The results have led to the assignment of coding triplets to each of the 20 naturally occurring amino-acids1,2. The peculiar feature of these codes is the presence of at least one uracil residue in each of the 20 triplets.

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References

  1. Speyer, J. F., Lengyel, P., Basilio, C., and Ochoa, S., Proc. U.S. Nat. Acad. Sci., 48, 441 (1962).

    Article  ADS  CAS  Google Scholar 

  2. Matthaei, J. H., Jones, O. W., Martin, R. G., and Nirenberg, M. W., Proc. U.S. Nat. Acad. Sci., 48, 666 (1962).

    Article  ADS  CAS  Google Scholar 

  3. Chargaff, E., Nature, 194, 86 (1962).

    Article  ADS  CAS  Google Scholar 

  4. Smith, E. L., Proc. U.S. Nat. Acad. Sci., 48, 859 (1962).

    Article  ADS  CAS  Google Scholar 

  5. Jukes, T. H., Biochem. Biophys. Res. Comm., 7, 497 (1962).

    Article  CAS  Google Scholar 

  6. Kassanis, B., and Nixon, H. L., J. Gen. Microbiol., 25, 459 (1962).

    Article  Google Scholar 

  7. Staehelin, M., Biochim. Biophys. Acta, 49, 11, 20, 27 (1961).

    Article  CAS  Google Scholar 

  8. Crick, F. H., Barnett, L., Brenner, S., and Watts-Tobin, R. J., Nature, 192, 1227 (1961).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Agricultural Research Council, Virus Research Unit, Huntingdon Road, Cambridge

    M. E. REICHMANN, M. W. REES, R. H. SYMONS & R. MARKHAM

  2. Canada Department of Agriculture, Research Station, Vancouver, B.C., Canada

    M. E. REICHMANN

Authors
  1. M. E. REICHMANN
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  2. M. W. REES
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  3. R. H. SYMONS
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  4. R. MARKHAM
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REICHMANN, M., REES, M., SYMONS, R. et al. Experimental Evidence for the Degeneracy of the Nucleotide Triplet Code. Nature 195, 999–1000 (1962). https://doi.org/10.1038/195999a0

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