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Effect of Ouabain on the Resting Tension and the Rate of Net Entry of Calcium-45 in Isolated Perfused Rabbit Ventricles

Nature volume 195, pages 294–295 (1962)Cite this article

Abstract

RECENT work in this laboratory has shown that in isolated rabbit atria the contracture induced by ouabain is probably the result of an increased calcium uptake1. Furthermore, it was shown that ouabain only affected calcium exchange that accompanies the process of activation2. Temperature studies revealed a high temperature coefficient (Q10) of 4–6 for both the effects on contracture and calcium-45 entry3. In this report we present the effects of ouabain on entry of calcium-45 and contracture in isolated perfused rabbit ventricles. The results indicate that contractures induced by the cardiac glycosides in both rabbit atria and ventricles are associated with an increased calcium entry.

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Authors and Affiliations

  1. Department of Pharmacology, University of Mississippi Medical Center, Jackson, Mississippi

    A. H. BRIGGS & W. C. HOLLAND

Authors
  1. A. H. BRIGGS
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  2. W. C. HOLLAND
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BRIGGS, A., HOLLAND, W. Effect of Ouabain on the Resting Tension and the Rate of Net Entry of Calcium-45 in Isolated Perfused Rabbit Ventricles. Nature 195, 294–295 (1962). https://doi.org/10.1038/195294a0

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