Abstract
SEVERAL reports have appeared recently regarding the effects of 5-fluoropyrimidines on nucleic acid metabolism1–10. One of these compounds, 5-fluorouracil, has been shown to exert a profound effect on the quantity of thymine component of nucleic acids, perhaps by interfering with the methylation of thymine1,2,8. Other investigators have shown that this fluoropyrimidine can be incorporated into UNA of tobacco mosaic virus, E. coli, mouse tumours and rat liver3–7,9,10. Horowitz et al. have also examined the effect of several other fluoro-derivatives as well as 5-fluorouracil on the synthesis of bacterial proteins and nucleic acids11. These investigators found that the 5-fluoropyrinudines invariably inhibited the synthesis of DNA in several strains of E. coli.
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LERMAN, S., DOYLE, J. & DOYLE, R. Effect of Fluorinated Pyrimidines on Herpes Simplex Virus. Nature 194, 986–988 (1962). https://doi.org/10.1038/194986a0
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DOI: https://doi.org/10.1038/194986a0
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