Abstract
IN order to investigate whether the basicity of the amino-acid residue at position 2 in hypertensin II has any strong bearing on its biological activity or affects the balance of oxytocic and pressor properties of this hormone, the histidine1–hypertensin analogue2 was synthesized in this laboratory. I used the procedure for histidyl peptides1, which also leads to the synthesis of the im. benzyl analogue. The latter might spread light on the biological significance of the imidazole ring of histidine.
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References
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THEODOROPOULOS, D. Synthesis of a Protected Octapeptide Analogue of Hypertensin II. Nature 194, 283–284 (1962). https://doi.org/10.1038/194283b0
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DOI: https://doi.org/10.1038/194283b0
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