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Fertilization of Rabbit Ova in vitro


A PREVIOUS communication1 has described a repeatable technique for the fertilization in vitro of rabbit ova, the transfer of which to recipient females resulted in the subsequent delivery of viable young. However, in these and experiments of other workers2,3 the rate of fertilization so far achieved in vitro is much below the 94 per cent4,5 normally obtained in vivo. Thus, it would seem to be of interest to report on the results of experiments carried out in an effort to raise the percentage of fertilization in vitro, and on some factors which may affect mammalian fertilization.

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  1. Chang, M. C., Nature, 184, 466 (1959).

    Article  ADS  Google Scholar 

  2. Dauzier, L., Thibault, C., and Wintenburger, S., C.R. Acad. Sci., Paris, 238, 844 (1954).

    CAS  Google Scholar 

  3. Dauzier, L., and Thibault, C., C.R. Acad. Sci., Paris, 248, 2655 (1959).

    CAS  Google Scholar 

  4. Chang, M. C., Fert. and Ster., 3, 251 (1952).

    Article  CAS  Google Scholar 

  5. Adams, C. E., J. Endocrinol., 13, 296 (1956).

    Article  CAS  Google Scholar 

  6. Hammond, jun., J., Nature, 163, 28 (1949).

    Article  ADS  Google Scholar 

  7. Dauzier, L., and Thibault, C., Fourth Intern. Cong. Anim. Rep. and Art. Ins., The Hague (1961).

  8. Chang, M. C., Nature, 179, 258 (1957).

    Article  ADS  CAS  Google Scholar 

  9. Thibault, C., and Dauzier, L., C.R. Acad. Sci., Paris, 250, 1358 (1960).

    CAS  Google Scholar 

  10. Runnstrom, J., Exp. Cell Res., 12, 374 (1957).

    Article  CAS  Google Scholar 

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BEDFORD, J., CHANG, M. Fertilization of Rabbit Ova in vitro. Nature 193, 898–899 (1962).

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