Letter | Published:

Total-Body Irradiation and Manganese Metabolism

Nature volume 193, pages 792793 (24 February 1962) | Download Citation

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Abstract

IN a previous communication1 it was reported that glucocorticoid hormones produced a specific metabolic alteration of manganese in mice. This manifested itself chiefly by a marked change in the partition of manganese-54 between the liver and the rest of the body: under treatment with glucocorticoids the concentration of manganese-54 decreased while the carcass concentration of the radioisotope increased at a much faster rate than in control animals. Mineralocorticoids did not produce this effect. None of the corticoids tested influenced the metabolism of another intracellular transition metal, namely, zinc-65.

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References

  1. 1.

    , and , Amer. J. Physiol. (in the press).

  2. 2.

    , and , Amer. J. Physiol., 177, 51 (1954).

  3. 3.

    , and , Rad. Res., 5, 58 (1956).

  4. 4.

    , Medical Radiation Biology (C. C. Thomas, Springfield, Illinois, 1959).

  5. 5.

    , and , J. Clin. Invest., 37, 1298 (1958).

  6. 6.

    , and , Science, 128, 988 (1958).

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Affiliations

  1. Medical Research Center, Brookhaven National Laboratory, Upton, Long Island, New York.

    • EDWIN R. HUGHES
    • , GEORGE C. COTZIAS
    •  & EUGENE P. CRONKITE

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https://doi.org/10.1038/193792a0

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