Abstract
IN a previous communication1 it was reported that glucocorticoid hormones produced a specific metabolic alteration of manganese in mice. This manifested itself chiefly by a marked change in the partition of manganese-54 between the liver and the rest of the body: under treatment with glucocorticoids the concentration of manganese-54 decreased while the carcass concentration of the radioisotope increased at a much faster rate than in control animals. Mineralocorticoids did not produce this effect. None of the corticoids tested influenced the metabolism of another intracellular transition metal, namely, zinc-65.
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References
Hughes, E. R., and Cotzias, G. C., Amer. J. Physiol. (in the press).
Nims, L. F., and Sutton, E., Amer. J. Physiol., 177, 51 (1954).
Nims, L. F., and Geisseloder, J., Rad. Res., 5, 58 (1956).
Ellinger, F., Medical Radiation Biology (C. C. Thomas, Springfield, Illinois, 1959).
Cotzias, G. C., and Greenough, J. J., J. Clin. Invest., 37, 1298 (1958).
Bertinchamps, A. J., and Cotzias, G. C., Science, 128, 988 (1958).
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HUGHES, E., COTZIAS, G. & CRONKITE, E. Total-Body Irradiation and Manganese Metabolism. Nature 193, 792–793 (1962). https://doi.org/10.1038/193792a0
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DOI: https://doi.org/10.1038/193792a0
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