Letter | Published:

Modification of the Growth-rate of Sarcoma-37 during Culture

Naturevolume 193pages790791 (1962) | Download Citation



THERE has been a conflict of opinion in the past as to whether tumour cells are altered in their biological properties when grown in contact with the chick embryo. Some workers have contended that an experience with the avian embryo does not provoke any readily recognizable transformation in the tumour cells1–3, while others4,5 take the opposing view. The present experimental work was designed to evaluate the effect of culture on one type of tumour (sarcoma-37) in several ways on one biological characteristic of the cells, namely, their growth potential.

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    Dagg, C. P., Karnofsky, D. A., Toolah, H. W., and Roddy, J., Proc. Soc. Exp. Biol. and Med., 87, 223 (1954).

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    Karnofsky, D. A., Ridgway, L. P., and Patterson, P. A., Ann. N.Y. Acad. Sci., 55, 313 (1952).

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    Korngold, L., and Lipari, R., Cancer Res., 15, 159 (1955).

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    Mirand, E. A., and Hoffman, J. G., Proc. Soc. Exp. Biol. and Med., 88, 656 (1955).

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    Pokrovskaya, T. A., Bull. Exp. Biol. Med. U.S.S.R. (English trans.), 48, 1403 (1960).

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    Spratt, jun., N. T., Science, 106, 452 (1947).

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    Fraser, R. C., Cancer Res., 19, 33 (1959).

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  1. Department of Zoology and Entomology, University of Tennessee, Knoxville, Tennessee

    • R. C. FRASER


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