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Inhibition of Kieselguhr Agglutination of Serum by Seromucoid and Pig Serum Glycoprotein Content

Naturevolume 193pages779780 (1962) | Download Citation



IN the course of an experiment, one of us (S. S.) found incidentally that sera such as human, bovine, guinea pig, rabbit and dog agglutinate kieselguhr but pig serum does not, and the mixture of serum and kieselguhr remains homogeneous1. We are interested in the chemical mechanism involved in agglutination and in the species difference. The occurrence of agglutination is considered, at least in part, as being due to the ionic interaction between positively charged ɛ-amino groups of lysine and negatively charged kieselguhr2. The inagglutinability of pig serum remained unexplained.

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  1. Institute for Tuberculosis and Leprosy, Tohoku University, Sendai

    • S. SATO
    • , T. AMIZUKA
    •  & K. SATO


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