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Dissociation of Thrombosthenin into Two Components comparable with Actin and Myosin

Naturevolume 193pages777778 (1962) | Download Citation



BLOOD platelets are capable of inducing the retraction of blood clots as well as of undergoing morphological and structural changes termed ‘viscous metamorphosis’. Both phenomena are manifestations of the same basic processes, and they are interlinked with the important functions of platelets in the hæmostatic mechanism. In 1959 we reported the isolation of a contractile protein from human blood platelets1. This material, afterwards termed ‘thrombosthenin’, accounts for 15 per cent of the platelet proteins, and most likely plays an important part in the functions of the platelet2.

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    Bettex-Galland, M., and Lüscher, E. F., Nature, 184, 276 (1959).

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    Bettex-Galland, M., and Lüscher, E. F., Biochim. Biophys. Acta, 49, 536 (1961).

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    Hoffmann-Berling, H., Biochim. Biophys. Acta, 19, 453 (1956).

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    Szent-Györgyi, A. G., J. Biol. Chem., 192, 361 (1951).

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    Bárány, M., Bárány, K., and Guba, F., Nature, 179, 818 (1957).

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    Bárány, M., and Jaisle, F., Biochim. Biophys. Acta, 41, 192 (1960).

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    Portzehl, H., Schramm, G., and Weber, H. H., Z. Naturforsch., 5, b, 61 (1950).

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  1. Theodor Kocher Institute, University of Berne

    • , H. PORTZEHL
    •  & E. F. LÜSCHER


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