Letter | Published:

Growth Stimulation of Mycobacterium tuberculosis H37Rv by Coenzyme Q10

Nature volume 193, pages 702703 (17 February 1962) | Download Citation

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Abstract

WE have reported that coenzyme Q10 will stimulate the growth of a scotochromogenic strain of Mycobacteria1. The basal medium used in the experiments was the liquid medium of Proskauer and Beck2 which contains, in addition to inorganic salts, asparagine as a nitrogen source and glycerol as an energy source. This medium will support slow growth of human varieties of Mycobacteria provided a heavy inoculum is used. In our experiments1 a small inoculum was used and no growth occurred. Addition of coenzyme Q10 and sodium lauryl sulphate to the medium permitted growth of the scotochromogenic Mycobacterium. Both the substances had to be added to stimulate growth. Under these same conditions growth of Mycobacterium tuberculosis H37Rv did not occur. We have now discovered that coenzyme Q10 will stimulate the growth of M. tuberculosis H37Rv if Proskauer and Beck medium is supplemented with pyruvate and succinate instead of lauryl sulphate.

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References

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    , and , Biochem. Biophys. Res. Comm., 2, 372 (1960).

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Author information

Affiliations

  1. Department of Microbiology, Baylor University College of Medicine, Houston 25, Texas.

    • JAMES O. NORMAN
    •  & ROBERT P. WILLIAMS

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DOI

https://doi.org/10.1038/193702a0

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