Letter | Published:

Time of Appearance of Lung Surfactant in the Fœtal Mouse

Naturevolume 193pages688689 (1962) | Download Citation

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Abstract

PATTLE1 first noted the stability of bubbles formed in the foam expressed from lungs of mature animals and the lack of stability in material from fœtal lungs. Clements2 emphasized the importance of a bubblestabilizing factor, that is, a surfactant, in the prevention of atelectasis. Lungs from human fœtuses of less than 1,000 gm. usually lack the surfactant characteristic of older fœtuses3; occasionally, lessmature fœtuses possess lung stability4.

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References

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    Pattle, R. E., Proc. Roy. Soc., B, 148, 217 (1958).

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    Avery, M. E., and Mead, J., Amer. J. Dis. Child., 97, 517 (1959).

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    Pattle, R. E., Nature, 189, 844 (1961). Buckingham, S., Thirty-first Ann. Meet. Soc. Ped. Res. May 4–5, 1961, Prog. and Abst., 68. Klaus, M., Clements, J., and Havel, R. J., Seventy-first Ann. Meet. Amer. Ped. Soc., May 2–3, 1961, Prog. and Abst., 28.

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    Woodside, G. L., and Dalton, A. J., J. Ultrastructure Res., 2, 28 (1958).

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    Schulz, H., The Submicroscopic Anatomy and Pathology of the Lung (Springer, Berlin, 1959).

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    Clements, J. A., Hustead, R. F., Johnson, R. P., and Gribetz, I., J. App. Physiol., 16, 444 (1961).

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Affiliations

  1. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, 5, Maryland

    • SUE BUCKINGHAM
    •  & MARY ELLEN AVERY

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https://doi.org/10.1038/193688a0

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