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Glucose-6-Phosphate Dehydrogenase Deficient Mutant in Human Cell Culture

Nature volume 193, pages 602–603 (1962)Cite this article

Abstract

THE examination of known human genetic differences in cell culture is a prerequisite to the establishment of a somatic cell genetics of man. The recent paper on the inability of cell cultures from galactosæmic subjects to utilize galactose is the first report of the maintenance of a genetically determined metabolic difference in cell culture1. In this communication we wish to report the results of work on glucose-6-phosphate dehydrogenase activities in cell cultures from a subject with a genetically determined deficiency of glucose-6-phosphate dehydrogenase activity and from a series of normal subjects.

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References

  1. Krooth, R. S., and Weinberg, A. N., Biochem. and Biophys. Res. Comm., 3, 518 (1960).

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  2. Edwards, J. H., Lancet, i, 496 (1960).

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Author notes

  1. STANLEY M. GARTLER: Senior Public Health Service Research Fellow.

Authors and Affiliations

  1. Departments of Medicine and Genetics, University of Washington, Seattle, and Istituto de Genetica Medica, Della Universita, Torino, Italy

    STANLEY M. GARTLER, ENRICO GANDINI & RUGGERO CEPPELLINI

Authors
  1. STANLEY M. GARTLER
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  2. ENRICO GANDINI
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  3. RUGGERO CEPPELLINI
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GARTLER, S., GANDINI, E. & CEPPELLINI, R. Glucose-6-Phosphate Dehydrogenase Deficient Mutant in Human Cell Culture. Nature 193, 602–603 (1962). https://doi.org/10.1038/193602a0

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