Letter | Published:

Cancer Subjects and Abnormal Cell Division

Nature volume 193, page 591 (10 February 1962) | Download Citation

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Abstract

WE reported recently that the proportions of aneuploid cells in cultures of human blood cells increased approximately in proportion to the age of the subject1. Some of the cells observed to have chromosome numbers less than normal are likely to have been artefacts. There was, however, evidence that others were genuinely abnormal, and it was concluded that the increase of abnormal cells with age indicates either a real increase in the number of aneuploid cells in the body or an increased liability to abnormal cell division. In either case it was possible that the finding was related to the increase in incidence that occurs with age in most types of cancer.

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References

  1. 1.

    , , and , Nature, 191, 1178 (1961).

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  1. Medical Research Council Clinical Effects of Radiation Research Unit, Western General Hospital, Edinburgh 6.

    • KARIN E. BUCKTON
    • , PATRICIA A. JACOBS
    • , W. M. COURT BROWN
    •  & R. DOLL

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https://doi.org/10.1038/193591a0

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