Abstract
WE reported recently that the proportions of aneuploid cells in cultures of human blood cells increased approximately in proportion to the age of the subject1. Some of the cells observed to have chromosome numbers less than normal are likely to have been artefacts. There was, however, evidence that others were genuinely abnormal, and it was concluded that the increase of abnormal cells with age indicates either a real increase in the number of aneuploid cells in the body or an increased liability to abnormal cell division. In either case it was possible that the finding was related to the increase in incidence that occurs with age in most types of cancer.
Similar content being viewed by others
Article PDF
References
Jacobs, P. A., Court Brown, W. M., and Doll, R., Nature, 191, 1178 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BUCKTON, K., JACOBS, P., BROWN, W. et al. Cancer Subjects and Abnormal Cell Division. Nature 193, 591 (1962). https://doi.org/10.1038/193591a0
Issue Date:
DOI: https://doi.org/10.1038/193591a0
This article is cited by
-
Male breast cancer, age and sex chromosome aneuploidy
British Journal of Cancer (2013)
-
Change of Human Chromosome Count Distributions with Age: Evidence for a Sex Difference
Nature (1963)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.