Letter | Published:

Effect of Particle Size on Blood Griseofulvin-Levels in Man

Naturevolume 193pages588589 (1962) | Download Citation



FOR some drugs both the degree of alimentary absorption and the consequent levels in the blood are inversely related to particle size. Here we summarize the results of experiments to investigate the relationship between the particle-size of griseofulvin and its level in the blood after oral administration of the drug.

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  1. 1

    Gooden, E. L., and Smith, C. M., Indust. Eng. Chem. (Anal. Ed.), 12, 479 (1940).

  2. 2

    Bedford, C., Child, K. J., and Tomich, E. G., Nature, 184, 364 (1959).

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  1. Glaxo Laboratories, Greenford Road, Greenford, Middlesex

    • R. M. ATKINSON
    • , K. J. CHILD
    •  & E. G. TOMICH


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