Letter | Published:

Effect of Inhibition on the Presynaptic Nerve Terminal in the Neuromuscular Junction of the Crayfish

Naturevolume 193pages587588 (1962) | Download Citation



IN the crayfish muscle stimulation of the inhibitory axon results in two inhibitory effects: (1) The conductance of the muscle membrane is increased by the released inhibitory transmitter1; (2) The amount of transmitter released on stimulation from the excitatory nerve ending is reduced2,3. The second effect was named ‘presynaptic inhibition’. In the present work the following hypothesis is tested: presynaptic inhibition is based on interference of the inhibitory transmitter with the action potential spreading into the nerve terminal.

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  1. 1

    Fatt, P., and Katz, B., J. Physiol., 123, 374 (1953).

  2. 2

    Dudel, J., and Kuffler, S. W., J. Physiol., 155, 543 (1961).

  3. 3

    Dudel, J., and Kuffler, S. W., Nature, 187, 247 (1960).

  4. 4

    Dudel, J., and Kuffler, S. W., J. Physiol., 155, 514 (1961).

  5. 5

    Kuffler, S. W., Harvey Lec., 54, 176 (1958–59).

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  1. Physiologisches Institut, Universität Heidelberg, Akademiestr. 3, Heidelberg



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