Abstract
IN the crayfish muscle stimulation of the inhibitory axon results in two inhibitory effects: (1) The conductance of the muscle membrane is increased by the released inhibitory transmitter1; (2) The amount of transmitter released on stimulation from the excitatory nerve ending is reduced2,3. The second effect was named ‘presynaptic inhibition’. In the present work the following hypothesis is tested: presynaptic inhibition is based on interference of the inhibitory transmitter with the action potential spreading into the nerve terminal.
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References
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DUBEL, J. Effect of Inhibition on the Presynaptic Nerve Terminal in the Neuromuscular Junction of the Crayfish. Nature 193, 587–588 (1962). https://doi.org/10.1038/193587b0
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DOI: https://doi.org/10.1038/193587b0
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