Abstract
ACETYLCHOLINE has been shown to increase potassium permeability in myocardial tissues1–3. Its effect on transport of sodium, however, is inconclusive. Earlier flux studies3,4 and, more recently, microelectrode studies5–7 suggest that acetylcholine (ACh) may have an effect on entry of sodium during the rising phase of the action potential. This communication deals with the effect of ACh on the rate of net entry of sodium-24 in isolated rabbit atria under different stimulus frequencies. The results presented may explain some of the findings of other investigators working on the effect of ACh, using the microelectrode technique.
Similar content being viewed by others
Article PDF
References
Holland, W. C., Dunn, C. E., and Greig, M. E., Amer. J. Physiol., 168, 546 (1952); 170, 339 (1952).
Harris, E. J., and Hutter, O. F., J. Physiol., 133, 58, P (1956).
Klein, R. L., and Holland, W. C., Amer. J. Physiol., 193, 239 (1958).
Holland, W. C., and Klein, R. L., Circ. Res., 6, 516 (1958).
Johnson, E. A., and McKinnon, M. G., J. Pharmacol. and Exp. Ther., 120, 460 (1957).
Johnson, E. A., and Robertson, P. A., Brit. J. Pharmacol., 13, 304 (1958).
Vaughn Williams, E. M., J. Physiol., 140, 327 (1958).
Holland, W. C., Klein, R. L., and Briggs, A. H., Amer. J. Physiol., 196, 478 (1958).
Klein, R. L., and Holland, W. C., Amer. J. Physiol., 196, 1292 (1959).
West, T. C., and Amory, D., J. Pharmacol. and Exp. Ther., 130, 183 (1960).
Weidmann, S., J. Physiol., 129, 568 (1955).
Klein, R. L., Holland, W. C., and Tinsley, B., Circ. Res., 8, 246 (1960).
Klein, R. L., and Holland, W. C., Amer. J. Physiol., 199, 346 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CERVONI, P., HOLLAND, W. Entry of Sodium-24 in Isolated Rabbit Atria. Nature 193, 586 (1962). https://doi.org/10.1038/193586a0
Issue Date:
DOI: https://doi.org/10.1038/193586a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.