Letter | Published:

Entry of Sodium-24 in Isolated Rabbit Atria

Nature volume 193, page 586 (10 February 1962) | Download Citation

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Abstract

ACETYLCHOLINE has been shown to increase potassium permeability in myocardial tissues1–3. Its effect on transport of sodium, however, is inconclusive. Earlier flux studies3,4 and, more recently, microelectrode studies5–7 suggest that acetylcholine (ACh) may have an effect on entry of sodium during the rising phase of the action potential. This communication deals with the effect of ACh on the rate of net entry of sodium-24 in isolated rabbit atria under different stimulus frequencies. The results presented may explain some of the findings of other investigators working on the effect of ACh, using the microelectrode technique.

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Affiliations

  1. Department of Pharmacology, University of Mississippi Medical Center, Jackson.

    • PETER CERVONI
    •  & WILLIAM C. HOLLAND

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https://doi.org/10.1038/193586a0

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