Abstract
Hebb and Whittaker1 have described the isolation of a sub-cellular fraction of brain tissue which contains bound acetylcholine and choline acetylase. This fraction was examined further by Whittaker2 with equilibrium centrifugation in a density gradient. His results appear to provide evidence for physiological significance of his “synaptic vesicle fraction”. We have also attempted to apply his fractionation method to study sub-cellular distribution of substance P in the nervous system.
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INOUYE, A., KATAOKA, K. Sub-cellular Distribution of the Substance P in the Nervous Tissues. Nature 193, 585 (1962). https://doi.org/10.1038/193585a0
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DOI: https://doi.org/10.1038/193585a0
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