Letter | Published:

Sub-cellular Distribution of the Substance P in the Nervous Tissues

Nature volume 193, page 585 (10 February 1962) | Download Citation

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Abstract

Hebb and Whittaker1 have described the isolation of a sub-cellular fraction of brain tissue which contains bound acetylcholine and choline acetylase. This fraction was examined further by Whittaker2 with equilibrium centrifugation in a density gradient. His results appear to provide evidence for physiological significance of his “synaptic vesicle fraction”. We have also attempted to apply his fractionation method to study sub-cellular distribution of substance P in the nervous system.

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Author information

Affiliations

  1. Department of Physiology, Faculty of Medicine, Kyoto University, Kyoto, Japan.

    • AKIRA INOUYE
    •  & KIYOSHI KATAOKA

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https://doi.org/10.1038/193585a0

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