Letter | Published:

Linkage between Glucose-6-Phosphate Dehydrogenase Deficiency and Colour-Blindness

Naturevolume 193page506 (1962) | Download Citation

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Abstract

A LINKAGE investigation has been carried out in American Negroes to confirm that deficiency in glucose-6-phosphate dehydrogenase is sex linked rather than sex limited1, and, if sex linked, to determine the recombination fraction (χ) between the loci for deficiency in glucose-6-phosphate dehydrogenase and colour-blindness; further, through the use of linkage, to see if the difference between the expression of deficiency in glucose-6-phosphate dehydrogenase in Negroes and Caucasians2 is explicable on the basis of different genetic loci in the different ethnic groups.

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References

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    Childs, B., Zinkham, W. H., Browne, E. A., Kimbro, E. L., and Torbett, J. H., Bull. Johns Hopkins Hosp., 102, 21 (1958).

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    Marks, P. A., and Gross, R. T., J. Clin. Invest., 38, 2253 (1959).

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    Motulsky, A. G., Proc. Conf. Genetic Polymorphisms and Geographic Variations in Disease, 270 (1960).

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    Glock, G. E., and McLean, P., Biochem. J., 55, 400 (1953).

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    Smith, C. A. B., J. Roy. Stat. Soc., B, 15, 153 (1953).

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    Adam, A., Nature, 189, 686 (1961).

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    Siniscalco, M., Second Intern. Conf. Human Genetics (1961).

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Affiliations

  1. Johns Hopkins Hospital, Baltimore, 5, Maryland

    • I. H. PORTER
    • , J. SCHULZE
    •  & V. A. McKUSICK

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https://doi.org/10.1038/193506a0

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