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Protective Action of 2,2-Diphenyl-4-Isopropylaminobutyramidmethyliodide on Reserpine-promoted Gastric Ulcers

Nature volume 193, pages 493–494 (1962)Cite this article

Abstract

THERE are numerous clinical data concerning the ulcer-inducing effect of reserpine1. A dose of 3–5 mgm. of reserpine causes hæmorrhagic erosions in the fundus of the stomach of the rat in 18 hr.2,3. Experimental ulcers in its squamous portion, caused by feeding the animals exclusively with glucose solution for 8–15 days, are significantly increased in number by administration of reserpine4. Reserpine sharply stimulates acid gastric secretion5; this effect can be prevented with atropine6. Prevention of the harmful effects of reserpine on the gastric mucosa with the aid of drugs in current clinical use is of practical and theoretical importance. Therefore, the purpose of the present work was to investigate the protective action of an anticholinergic drug, 2,2-diphenyl-4-isopropylaminobutyramidmethyl-iodide. We are grateful to Messrs. Ciba A.G., Basel, who supplied ‘Serpasil’, and to Messrs. Oy. Orion, Helsinki, for the supply of the anticholinergic agent (‘Neopant’).

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Authors and Affiliations

  1. Department of Anatomy, University of Helsinki, Siltavuorenpenger 20, Helsinki

    ERKKI O. JÄNKÄLÄ & PEKKA VIRTAMA

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  1. ERKKI O. JÄNKÄLÄ
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  2. PEKKA VIRTAMA
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JÄNKÄLÄ, E., VIRTAMA, P. Protective Action of 2,2-Diphenyl-4-Isopropylaminobutyramidmethyliodide on Reserpine-promoted Gastric Ulcers. Nature 193, 493–494 (1962). https://doi.org/10.1038/193493a0

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