Letter | Published:

A Rat Serum Protein related to Reproduction, Tissue Synthesis and Lactation

Naturevolume 193page491 (1962) | Download Citation



DARCY1,2 has demonstrated by immunoelectrophoresis the presence of a protein in the sera of fœtal, neonatal, pregnant, tumour-bearing and regenerating rats not found in the sera of healthy, non-pregnant adults of either sex. More recently, Beaton et al.3,4 and Heim5 have shown, in the sera of pregnant and neonatal rats, the existence of a distinct protein component in the electrophoretic pattern obtained by starch-gel electrophoresis which is absent from the patterns of sera from healthy, non-pregnant, adult rats. Beaton et al.4 also demonstrated this component in certain pathological conditions and Heim5 found it in sera from fœtal and lactating rats. The presence or absence of the new component, hereinafter termed reproduction-associated protein, has now been determined over most of the life-cycle of the rat and under certain experimental conditions. A hypothesis of identity of the reproduction-associated protein with the protein discovered by Darcy1 is suggested.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Darcy, D. A., Brit. J. Cancer, 11, 137 (1957).

  2. 2

    Darcy, D. A., Brit. J. Cancer, 14, 524 (1960).

  3. 3

    Beaton, G. H., and Selby, A. E., Fed. Proc., 19, Pt. 1, 74 (1960).

  4. 4

    Beaton, G. H., Selby, A. E., Veen, M. J., and Wright, A. M., J. Biol. Chem., 236, 2005 (1961).

  5. 5

    Heim, W. G., Amer. Zool., 1, 359 (1961).

  6. 6

    Heim, W. G., J. Embryol. Exp. Morph., 9, 52 (1961).

  7. 7

    Smithies, O., Biochem. J., 71, 585 (1959).

  8. 8

    Smithies, O., Adv. Protein Chem., 14, 65 (1959).

  9. 9

    Darcy, D. A., Brit. J. Cancer, 14, 534 (1960).

  10. 10

    Beaton, G. H., Selby, A. E., and Wright, A. M., J. Biol. Chem., 236, 2001 (1961).

Download references

Author information


  1. Department of Biology, Wayne State University, Detroit, 2, Michigan



  1. Search for WERNER G. HEIM in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.