Letter | Published:

Difference in Gross Structure of Two Electrophoretically Identical ‘Minor’ Hæmoglobin Components

Nature volume 193, pages 489491 (03 February 1962) | Download Citation

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Abstract

DURING a search for the possible presence of abnormal hæmoglobin types in the white population of the south-eastern area of the United States, minor hæmoglobin variants were discovered in the blood of two healthy adult males, both being admitted to the VA Hospital, Augusta, Georgia, for reasons not related to any hæmatological abnormality. In paper electrophoresis at pH 8.6 both components showed an electrophoretic mobility slightly faster than hæmoglobin-S (Hb-S), while in starch-gel electrophoresis1,2 at pH 8.0 they were indistinguishable from Hb-S. The amounts present were considerably less than usually found in the blood of an abnormal hæmoglobin trait carrier; in both cases the per cent abnormal component was estimated between 10 and 15 per cent.

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Author information

Affiliations

  1. Departments of Biochemistry and Pathology,

    • TITUS H. J. HUISMAN
  2. V.A. Hospital and Department of Medicine, Medical College of Georgia, Augusta, Georgia.

    • VIRGIL P. SYDENSTRICKER

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DOI

https://doi.org/10.1038/193489a0

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