Letter | Published:

Accumulation of S-Sulphocysteine by a Mutant Strain of Aspergillus nidulans

Nature volume 193, pages 481482 (03 February 1962) | Download Citation

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Abstract

RECENT work in this laboratory1,2, together with earlier observations by Hockenhull3, have provided strong evidence indicating that in Aspergillus nidulans cysteine is synthesized from inorganic sulphur sources via S-sulphocysteine (cysteine-S-sulphonate) as the immediate precursor. This latter compound has, however, not yet been reported to occur in micro-organisms. In the present communication we report that a mutant strain of A. nidulans actually accumulates radioactive S-sulphocysteine when grown in a medium containing sulphate labelled with sulphur-35. The mutant used, strain 793, has been shown to be genetically blocked in the reaction by which S-sulphocysteine is converted to cysteine1,2.

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References

  1. 1.

    , and , Nature, 185, 163 (1960).

  2. 2.

    , J. Gen. Microbiol. (in the press).

  3. 3.

    , Biochim. Biophys. Acta, 3, 326 (1949).

  4. 4.

    , and , J. Gen. Microbiol., 22, 520 (1960).

  5. 5.

    , J. Chem. Soc., 1515 (1949).

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Affiliations

  1. Institute for Protein Research, Osaka University, Kita-Ku, Osaka, Japan.

    • TARO NAKAMURA
    •  & RYO SATO

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https://doi.org/10.1038/193481a0

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