Letter | Published:

Hæmolytic Activity of Vitamin K3: Evidence for a Direct Effect on Cellular Enzymes

Nature volume 193, pages 480481 (03 February 1962) | Download Citation

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Abstract

THERE is considerable controversy concerning the mechanism of the so-called drug-induced hæmolytie anæmias and the mechanism and significance of Heinz body formation in red blood cells. Harley et al.1 were one of three groups of investigators2,3 who found independently that the various oxidant drugs which have been implicated in the causation of hæmolytic anæmia have a profound effect on intracellular hæmoglobin, and that oxidation of hæmoglobin may be an important part of the mechanism whereby these drugs lead to shortening of the life-span of red blood cells. Before the publication by the three groups mentioned, Beutler4 in a comprehensive review denied this possibility.

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References

  1. 1.

    a, , and , Blood, 16, 1722 (1960); b, ibid., 17, 419 (1961); c, , and (preceding communication).

  2. 2.

    a, , Kernicterus, 68 (Univ. Toronto Press, Toronto, 1961); b, , , and , Nature, 188, 316 (1960); c, , , and , Acta Chem. Scand., 14, 1847 (1960).

  3. 3.

    a, , and , J. Clin. Invest., 39, 1000 (1960); b, , , and , ibid., 39, 1818 (1960); c, , and , ibid., 40, 454 (1961).

  4. 4.

    , Blood, 14, 103 (1959).

  5. 5.

    , and (unpublished work).

  6. 6.

    , , , and , J. Biol. Chem., 227, 261 (1957).

  7. 7.

    , , and (unpublished work).

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Author information

Author notes

    • ANDREW SASS-KORTSAK

    Permanent address: Research Institute of the Hospital for Sick Children, Toronto, Canada.

Affiliations

  1. Wenner-Gren Institute, University of Stockholm.

    • ANDREW SASS-KORTSAK
    • , BERTIL THALME
    •  & LARS ERNSTER

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DOI

https://doi.org/10.1038/193480a0

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