Letter | Published:

Hæmolytic Activity of Vitamin K3: Evidence for a Direct Effect on Cellular Enzymes

Naturevolume 193pages480481 (1962) | Download Citation



THERE is considerable controversy concerning the mechanism of the so-called drug-induced hæmolytie anæmias and the mechanism and significance of Heinz body formation in red blood cells. Harley et al.1 were one of three groups of investigators2,3 who found independently that the various oxidant drugs which have been implicated in the causation of hæmolytic anæmia have a profound effect on intracellular hæmoglobin, and that oxidation of hæmoglobin may be an important part of the mechanism whereby these drugs lead to shortening of the life-span of red blood cells. Before the publication by the three groups mentioned, Beutler4 in a comprehensive review denied this possibility.

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  1. 1

    a, Harley, J. D., and Mauer, A. M., Blood, 16, 1722 (1960); b, ibid., 17, 419 (1961); c, Harley, J. S., and Robin, H. (preceding communication).

  2. 2

    a, Ernster, L., Kernicterus, 68 (Univ. Toronto Press, Toronto, 1961); b, Broberger, O., Ernster, L., and Zetterström, R., Nature, 188, 316 (1960); c, Sass-Kortsak, A., Thalme, B., and Ernster, L., Acta Chem. Scand., 14, 1847 (1960).

  3. 3

    a, Jandl, J. H., and Allen, D. W., J. Clin. Invest., 39, 1000 (1960); b, Jandl, J. H., Engle, L. K., and Allen, D. W., ibid., 39, 1818 (1960); c, Allen, D. W., and Jandl, J. H., ibid., 40, 454 (1961).

  4. 4

    Beutler, E., Blood, 14, 103 (1959).

  5. 5

    Thalme, B., and Ernster, L. (unpublished work).

  6. 6

    Huennekens, F. M., Caffrey, R. W., Basford, R. E., and Gabrio, B. W., J. Biol. Chem., 227, 261 (1957).

  7. 7

    Sass-Kortsak, A., Thalme, B., and Ernster, L. (unpublished work).

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  1. Wenner-Gren Institute, University of Stockholm

  2. Research Institute of the Hospital for Sick Children, Toronto, Canada



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