Letter | Published:

Presence of N-Methylmetadrenaline in Human Urine and Tumour Tissue of Phæochromocytoma

Nature volume 193, pages 477478 (03 February 1962) | Download Citation

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Abstract

IN 1960, Axelrod1 found N-methyladrenaline in adrenal glands of several animals and a large quantity of N-methylmetadrenaline in the urine from the rat administered with N-methyladrenaline. On these findings a new metabolic pathway of adrenaline involving its N-methylation was suggested. The possibility of this new pathway of adrenaline in human beings has been investigated.

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References

  1. 1.

    , Biochim. Biophys. Acta, 45, 614 (1960).

  2. 2.

    , , , , and , Nature, 191, 599 (1961).

  3. 3.

    , , , , and , Tohoku J. Exp. Med., 74, 105 (1961).

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  1. Department of Internal Medicine, Tohoku University School of Medicine, Sendai.

    • CHUICHI ITOH
    • , KAORU YOSHINAGA
    • , TATSUO SATO
    • , NOZOMU ISHIDA
    •  & YASUO WADA

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https://doi.org/10.1038/193477b0

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